Coupled Receptor on NMDA Receptor Selectively Activates the NMDA Receptor/Ca /Calcineurin/cAMP Response Element-Binding Protein-Regulated Transcriptional Coactivator 1 Pathway to Effectively Induce Brain-Derived Neurotrophic Factor Expression in Neurons
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چکیده
Mamoru Fukuchi,1 Akiko Tabuchi,1 Yuki Kuwana,1 Shinjiro Watanabe,1 Minami Inoue,1 Ichiro Takasaki,2 Hironori Izumi,3 Ayumi Tanaka,3 Ran Inoue,3 Hisashi Mori,3 Hidetoshi Komatsu,4 Hiroshi Takemori,5 Hiroyuki Okuno,6 Haruhiko Bito,6 and Masaaki Tsuda1 1Department of Biological Chemistry, Graduate School of Medicine and Pharmaceutical Sciences, 2Division of Molecular Genetics Research, Life Science Research Center, and 3Department of Molecular Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan, 4CNS Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical, Fujisawa, Kanagawa 251-8555, Japan, 5Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Saito, Ibaraki, Osaka 567-0085, Japan, and 6Department of Neurochemistry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
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تاریخ انتشار 2015